Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10615
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dc.contributor.authorZulli, Anthony-
dc.contributor.authorBurrell, Louise Men
dc.contributor.authorBuxton, Brian F-
dc.contributor.authorHare, David L-
dc.date.accessioned2015-05-16T00:07:45Z
dc.date.available2015-05-16T00:07:45Z
dc.date.issued2008-01-03en
dc.identifier.citationEuropean Journal of Histochemistry : Ejh; 52(1): 39-44en
dc.identifier.govdoc18502721en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10615en
dc.description.abstractA growing body of evidence suggests that the angiotensin II fragments, Ang(1-7) and Ang(3-8), have a vasoactive role, however ACE2, the enzyme that produces Ang(1-7), or AT4R, the receptor that binds Ang (3-8), have yet been simultaneously localised in both normal and diseased human conduit blood vessels. We sought to determine the immunohistochemical distribution of ACE2 and the AT4R in human internal mammary and radial arteries from patients undergoing coronary artery bypass surgery. We found that ACE2 positive cells were abundant in both normal and diseased vessels, being present in neo-intima and in media. ACE2 positive immunoreactivity was not present in the endothelial layer of the conduit vessels, but was clearly evident in small newly formed angiogenic vessels as well as the vaso vasorum. Endothelial AT4R immunoreactivity were rarely observed in either normal and diseased arteries, but AT4R positive cells were observed adjacent to the internal elastic lamine in the internal mammary artery, in the neo-intima of radial arteries, as well as in the media of both internal mammary artery and radial artery. AT4R was abundant in vaso vasorum and within small angiogenic vessels. Both AT4R and ACE2 co-localised with smooth muscle cell alpha actin. This study identifies smooth muscle cell alpha actin positive ACE2 and AT4R in human blood vessels as well as in angiogenic vessels, indicating a possible role for these enzymes in pathological disease.en
dc.language.isoenen
dc.subject.otherActins.analysisen
dc.subject.otherCoronary Artery Bypassen
dc.subject.otherCoronary Artery Disease.enzymology.metabolismen
dc.subject.otherEndothelium, Vascular.chemistry.enzymologyen
dc.subject.otherHumansen
dc.subject.otherMammary Arteries.chemistry.cytology.enzymologyen
dc.subject.otherMuscle, Smooth, Vascular.chemistry.enzymologyen
dc.subject.otherMyocytes, Smooth Muscle.chemistry.enzymologyen
dc.subject.otherPeptidyl-Dipeptidase A.analysisen
dc.subject.otherRadial Artery.chemistry.cytology.enzymologyen
dc.subject.otherReceptors, Angiotensin.analysisen
dc.titleACE2 and AT4R are present in diseased human blood vessels.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean journal of histochemistry : EJHen
dc.identifier.affiliationDepartment of Cardiology, Austin Health, Heidelberg 3084, Australiaen
dc.description.pages39-44en
dc.identifier.orcid0000-0001-9554-6556-
dc.identifier.pubmedid18502721-
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiac Surgery-
crisitem.author.deptCardiology-
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