Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10601
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dc.contributor.authorZulli, Anthony-
dc.contributor.authorBuxton, Brian F-
dc.contributor.authorMerrilees, Mervyn-
dc.contributor.authorHare, David L-
dc.date.accessioned2015-05-16T00:06:41Z
dc.date.available2015-05-16T00:06:41Z
dc.date.issued2008-05-01en
dc.identifier.citationHuman Pathology; 39(5): 657-65en
dc.identifier.govdoc18439939en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10601en
dc.description.abstractRecent evidence suggests that smooth muscle cells within the intima of diseased human blood vessels of the elderly population contain the embryonic form of smooth muscle cells. We wanted to explore the idea that human diseased vessels may contain other primitive cell types, such as pluripotent embryonic stem cells and hematopoietic stem cells. Radial and internal mammary arteries were collected from patients undergoing coronary artery bypass surgery; and coronary arteries, from hearts at autopsy and transplant. Immunohistochemistry was used to identify the embryonic stem cell markers Octomer-4; stage-specific embryonic antigens 1, 3, and 4; TRA-1-60; and TRA-1-81, and the leukocytic markers CD34, CD14, CD133, and CD64 in all vessels. We found that diseased human radial arteries contained the highest numbers of cells in the media- and intima-expressing markers of embryonic and leukocytic origin compared with diseased human coronary arteries. In nondiseased human vessels (internal mammary arteries), such cells were rarely observed. Granulation tissue within the diseased human arteries contained similar cells, and the angiogenic vessel endothelial cell layer also expressed these markers. It is concluded that diseased human blood vessels contain cells that express markers from leukocytic and embryonic origin. These results suggest that cells within human arteries might be able to differentiate into various cell types and that blood vessels might be a reservoir for such cells.en
dc.language.isoenen
dc.subject.otherAntigens, CD.analysisen
dc.subject.otherAntigens, CD14.analysisen
dc.subject.otherAntigens, CD15.analysisen
dc.subject.otherAntigens, CD34.analysisen
dc.subject.otherAntigens, Surface.analysisen
dc.subject.otherAntigens, Tumor-Associated, Carbohydrate.analysisen
dc.subject.otherArterial Occlusive Diseases.pathologyen
dc.subject.otherBiological Markers.analysisen
dc.subject.otherCoronary Artery Bypassen
dc.subject.otherEmbryonic Stem Cells.chemistryen
dc.subject.otherFemaleen
dc.subject.otherGlycoproteins.analysisen
dc.subject.otherGlycosphingolipids.analysisen
dc.subject.otherHumansen
dc.subject.otherImmunohistochemistryen
dc.subject.otherLeukocytes.pathologyen
dc.subject.otherMaleen
dc.subject.otherMammary Arteries.chemistry.pathologyen
dc.subject.otherOctamer Transcription Factor-3.analysisen
dc.subject.otherPeptides.analysisen
dc.subject.otherProteoglycans.analysisen
dc.subject.otherRadial Artery.chemistry.pathologyen
dc.subject.otherReceptors, IgG.analysisen
dc.subject.otherStage-Specific Embryonic Antigensen
dc.subject.otherTunica Intima.pathologyen
dc.titleHuman diseased arteries contain cells expressing leukocytic and embryonic stem cell markers.en
dc.typeJournal Articleen
dc.identifier.journaltitleHuman pathologyen
dc.identifier.affiliationDepartment of Cardiology, University of Melbourne, Austin Health, Heildelberg 3084, Australiaen
dc.identifier.doi10.1016/j.humpath.2007.09.022en
dc.description.pages657-65en
dc.identifier.orcid0000-0001-9554-6556-
dc.identifier.pubmedid18439939-
dc.type.austinJournal Articleen
local.name.researcherBuxton, Brian F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiac Surgery-
crisitem.author.deptCardiology-
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