Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10594
Title: The pursuit of a high central venous oxygen saturation in sepsis: growing concerns.
Authors: Bellomo, Rinaldo;Reade, Michael C;Warrillow, Stephen J
Affiliation: Department of Intensive Care, Austin Hospital, Studley Rd, Heidelberg, Victoria 3084, Australia. Rinaldo.bellomo@austin.org.au
Issue Date: 7-Apr-2008
Citation: Critical Care (london, England) 2008; 12(2): 130
Abstract: In this issue of Critical Care, Dutch investigators report that, in a cohort of patients with sepsis/septic shock admitted to three different intensive care units (ICUs), low central venous oxygen saturation (ScvO2) was uncommon at the time of ICU admission, and hospital mortality was <30%. Their findings, taken together with those of recent reports from Australia and New Zealand (ANZ), raise serious concerns about the utility of early goal directed therapy (EGDT) outside the context of the original trial. Despite inclusion of EGDT into the Surviving Sepsis Guidelines, in response to growing uncertainty, ANZ and US investigators will soon begin randomization of patients into two large multicentre trials comparing EGDT to standard therapy. Until such studies are completed, basing international treatment guidelines on a single centre study performed in what may turn out to be a highly atypical environment would seem premature.
Internal ID Number: 18423058
URI: http://ahro.austin.org.au/austinjspui/handle/1/10594
DOI: 10.1186/cc6841
URL: http://www.ncbi.nlm.nih.gov/pubmed/18423058
Type: Journal Article
Subjects: APACHE
Aged
Blood Gas Analysis.methods
Critical Illness
Female
Hematocrit
Humans
Hydrogen-Ion Concentration
Incidence
Intensive Care Units
Lactates.blood
Male
Netherlands
Observation
Oxygen.blood
Prognosis
Shock, Septic.blood
Appears in Collections:Journal articles

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