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dc.contributor.authorPremaratne, Eroshaen
dc.contributor.authorMacIsaac, Richard Jen
dc.contributor.authorFinch, Sueen
dc.contributor.authorPanagiotopoulos, Siannaen
dc.contributor.authorEkinci, Elif Ien
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-16T00:02:51Z-
dc.date.available2015-05-16T00:02:51Z-
dc.date.issued2008-03-04en
dc.identifier.citationDiabetes Care 2008; 31(5): 971-3en
dc.identifier.govdoc18319326en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10551en
dc.description.abstractCystatin C-and creatinine-based methods were compared with (99m)-technetium-diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function.Glomerular filtration rate (GFR) was monitored over a mean of 10.1 years in 85 subjects with type 1 diabetes (with an average of 5.6 measurements per individual). Baseline mean +/- SD iGFR of the cohort was 106.1 +/- 2.6 ml/min per 1.73 m(2). The rates of decline in GFR (DeltaGFR) were derived using linear regression.In 19 of 85 subjects with declining renal function (i.e., DeltaiGFR >3.3 ml/min per 1.73 m(2) per year), DeltaGFR (ml/min per 1.73 m(2) per year) was 6.5 by iGFR, 4.2 by 10(4)/creatinine, 3.6 by Cockcroft-Gault formula, 3.4 by the Modification of Diet in Renal Disease (MDRD)-6 equation, and 3.5 by the MDRD-4 variable equation (P < 0.01 vs. iGFR). In comparison, DeltaGFR was 6.1 using the formula Cys-GFR = (86.7/cystatin C concentration) - 4.2 (not significant).Cystatin C was more accurate in detecting decline in renal function than creatinine-based methods in this population of subjects with type 1 diabetes and a normal mean baseline GFR.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAsian Continental Ancestry Groupen
dc.subject.otherAustraliaen
dc.subject.otherCreatinine.blooden
dc.subject.otherCystatin Cen
dc.subject.otherCystatins.blooden
dc.subject.otherDiabetes Mellitus, Type 1.blood.complications.physiopathologyen
dc.subject.otherDiabetic Nephropathies.blood.diagnosis.physiopathologyen
dc.subject.otherEuropean Continental Ancestry Groupen
dc.subject.otherFemaleen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherHumansen
dc.subject.otherKidney Function Testsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherReproducibility of Resultsen
dc.titleSerial measurements of cystatin C are more accurate than creatinine-based methods in detecting declining renal function in type 1 diabetes.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetes careen
dc.identifier.affiliationEndocrine Centre, Austin Health, University of Melbourne, Melbourne, Australiaen
dc.identifier.doi10.2337/dc07-1588en
dc.description.pages971-3en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18319326en
dc.identifier.orcid0000-0002-0845-0001-
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