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|Title:||[125I]Ifenprodil: a convenient radioligand for binding and autoradiographic studies of the polyamine-sensitive site of the NMDA receptor.|
|Authors:||Beart, P M;Mercer, L D;Jarrott, B|
|Affiliation:||University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Vic. Australia.|
|Citation:||Neuroscience Letters; 124(2): 187-9|
|Abstract:||Iodination of ifenprodil, a non-competitive NMDA antagonist, with Na125I/Chloramin-T gave a radioligand which bound rapidly and saturably to a single population of sites (dissociation constant 145 nM) in membranes of rat cerebral cortex. In competition studies, specific binding of [125I]-ifenprodil was inhibited by analogues of ifenprodil, as well as by spermine and spermidine. Binding was sensitive to Ca2+, Mg2+ and Zn2+. [125I]-Ifenprodil labelled a population of binding sites, which was topographically distributed in rat forebrain, as shown by autoradiography. [125I]Ifenprodil is a useful radioligand for the investigation of the polyamine site of the N-methyl-D-aspartate (NMDA) receptor-complex.|
|Internal ID Number:||1829796|
Cerebral Cortex.drug effects.metabolism
Iodine Radioisotopes.diagnostic use
Piperidines.chemical synthesis.diagnostic use
Receptors, N-Methyl-D-Aspartate.drug effects
|Appears in Collections:||Journal articles|
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