Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10540
Title: Reduction in left ventricular mass in normotensive and spontaneously hypertensive rats given enalapril.
Authors: Mooser, V;Casley, David J;Trinder, D;Paxton, D;Johnston, Colin I
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-May-1991
Citation: Clinical and Experimental Pharmacology & Physiology; 18(5): 341-4
Abstract: 1. To test the hypothesis that the reduction of left ventricular weight (LVW) observed during angiotensin-converting enzyme (ACE) inhibition in rats is mainly a response to decreased cardiac load, the effect of enalapril on LVW and blood pressure (BP) in normotensive Sprague-Dawley (SD) and in spontaneously hypertensive rats (SHR) was compared. 2. Enalapril decreased BP by 10% in SD rats and 21% in SHR; and LVW by 6% in SD rats and 12% in SHR. A close linear correlation between BP and LVW was observed in SD (r = 0.65, n = 24, P less than 0.001) and SHR (r = 0.92, n = 15, P less than 0.001). 3. The effect of enalapril on LVW, when related to BP, was almost identical in SD and SHR, as the average reduction of LVW (microgram/g of bodyweight) per mmHg was 7.7 +/- 1.9 versus 7.5 +/- 0.9 in SD and SHR respectively. 4. These data constitute additional evidence to support the view that, at least under ACE inhibition, reduction in LVW is mainly due to the fall in BP and the decreased cardiac load.
Internal ID Number: 1829664
URI: http://ahro.austin.org.au/austinjspui/handle/1/10540
URL: http://www.ncbi.nlm.nih.gov/pubmed/1829664
Type: Journal Article
Subjects: Angiotensin-Converting Enzyme Inhibitors.pharmacology
Animals
Blood Pressure.drug effects
Cardiomegaly.chemically induced
Enalapril.blood.pharmacology
Heart.anatomy & histology.drug effects
Heart Ventricles.anatomy & histology.drug effects
Myocardium.enzymology
Organ Size.drug effects
Rats
Rats, Inbred SHR
Rats, Inbred Strains
Systole.drug effects
Appears in Collections:Journal articles

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