Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10539
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPeyton, Philip Jen
dc.contributor.authorHorriat, Maryamen
dc.contributor.authorRobinson, Gavin J Ben
dc.contributor.authorPierce, Robert Jen
dc.contributor.authorThompson, Bruce Ren
dc.date.accessioned2015-05-16T00:01:46Z
dc.date.available2015-05-16T00:01:46Z
dc.date.issued2008-03-01en
dc.identifier.citationAnesthesiology; 108(3): 381-7en
dc.identifier.govdoc18292675en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10539en
dc.description.abstractA number of studies have demonstrated a faster rate of increase in end-expired partial pressure as a fraction of inspired (Pa/Pi) for volatile agents in the presence of high concentrations of nitrous oxide, consistent with the second gas effect. However, no study has demonstrated a similar effect on arterial blood concentrations.The authors compared arterial and end-tidal partial pressures of sevoflurane (Pa/Pisevo and Pa/Pisevo) in 14 patients for 30 min after introduction of either 70% nitrous oxide or nitrous oxide-free gas mixtures to determine the magnitude of the second gas effect. Blood partial pressures were measured using a double headspace equilibration technique.Both Pa/Pisevo and Pa/Pisevo were significantly higher in the nitrous oxide group than in the control group (P < 0.001 on two-way analysis of variance). This difference was significantly greater (P < 0.05) for Pa/Pisevo (23.6% higher in the nitrous oxide group at 2 min, declining to 12.5% at 30 min) than for Pa/Pisevo (9.8% higher in the nitrous oxide group at 2 min) and was accompanied by a significantly lower Bispectral Index score at 5 min (40.7 vs. 25.4; P = 0.004).Nitrous oxide uptake exerts a significant second gas effect on arterial sevoflurane partial pressures. This effect is two to three times more powerful than the effect on end-expired partial pressures. The authors explain how this is due to the influence of ventilation-perfusion scatter on the distribution of blood flow and gas uptake in the lung.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAnesthesia, Inhalation.methodsen
dc.subject.otherBlood Gas Analysis.methodsen
dc.subject.otherCatheters, Indwellingen
dc.subject.otherExhalation.drug effects.physiologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMethyl Ethers.blooden
dc.subject.otherMiddle Ageden
dc.subject.otherNitrous Oxide.blood.pharmacokineticsen
dc.subject.otherPartial Pressureen
dc.titleMagnitude of the second gas effect on arterial sevoflurane partial pressure.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnesthesiologyen
dc.identifier.affiliationDepartment of Anaesthesia, Austin Hospital, Heidelberg, Melbourne, Australiaen
dc.identifier.affiliationphil.peyton@austin.org.auen
dc.identifier.doi10.1097/ALN.0b013e318164caf3en
dc.description.pages381-7en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18292675en
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.