Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10518
Title: Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin.
Authors: Aston-Mourney, Kathryn;Proietto, Joseph;Morahan, G;Andrikopoulos, Sofianos
Affiliation: The University of Melbourne Department of Medicine (AH/NH), Heidelberg Repatriation Hospital, Building 24, 300 Waterdale Road, Heidelberg Heights VIC 3081, Australia.
Issue Date: 2-Feb-2008
Citation: Diabetologia 2008; 51(4): 540-5
Abstract: In many countries, first- or second-line pharmacological treatment of patients with type 2 diabetes consists of sulfonylureas (such as glibenclamide [known as glyburide in the USA and Canada]), which stimulate the beta cell to secrete insulin. However, emerging evidence suggests that forcing the beta cell to secrete insulin at a time when it is struggling to cope with the demands of obesity and insulin resistance may accelerate its demise. Studies on families with persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI), the primary defect of which is hypersecretion of insulin, have shown that overt diabetes can develop later in life despite normal insulin sensitivity. In addition, in vitro experiments have suggested that reducing insulin secretion from islets isolated from patients with diabetes can restore insulin pulsatility and improve function. This article will explore the hypothesis that forcing the beta cell to hypersecrete insulin may be counterproductive and lead to dysfunction and death via mechanisms that may involve the endoplasmic reticulum and oxidative stress. We suggest that, in diabetes, therapeutic approaches should be targeted towards relieving the demand on the beta cell to secrete insulin.
Internal ID Number: 18246324
URI: http://ahro.austin.org.au/austinjspui/handle/1/10518
DOI: 10.1007/s00125-008-0930-2
URL: http://www.ncbi.nlm.nih.gov/pubmed/18246324
Type: Journal Article
Subjects: Diabetes Mellitus.etiology.physiopathology
Humans
Hyperinsulinism.complications.etiology.physiopathology
Insulin.secretion
Insulin-Secreting Cells.pathology.secretion
Oxidative Stress
Appears in Collections:Journal articles

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