Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10504
Title: Gastrin is not required for liver regeneration.
Authors: Dizdarevic, Amra;Harun, Nadia;Malcontenti-Wilson, Caterina;Shulkes, Arthur;Christophi, Christopher;Baldwin, Graham S
Affiliation: Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.
Issue Date: 2-Jan-2008
Citation: Anz Journal of Surgery; 78(1-2): 68-71
Abstract: Although several growth factors are known to be essential for liver regeneration, the role of gastrin remains controversial.Liver regeneration was examined in wild-type (WT) and gastrin-deficient (gastrin KO) mice at days 2 and 10 after partial (40%) hepatectomy by measurement of liver weight. Hepatocyte proliferation and circulating gastrin concentrations were measured at the same time points by immunohistochemistry and radioimmunoassay, respectively.There was no significant difference in the rate of liver regeneration between gastrin KO and WT mice. Hepatocyte proliferation in both groups was increased at day 2 but had returned to baseline values by day 10. At day 2, hepatocyte proliferation in the gastrin KO mice was significantly higher than in WT animals, whereas at day 10, proliferation was significantly greater in the WT mice. The circulating gastrin concentration in the WT mice was significantly lower at day 10 than in unoperated WT animals.This study suggests that gastrin is not essential for liver regeneration after partial hepatectomy.
Internal ID Number: 18199210
URI: http://ahro.austin.org.au/austinjspui/handle/1/10504
DOI: 10.1111/j.1445-2197.2007.04360.x
URL: http://www.ncbi.nlm.nih.gov/pubmed/18199210
Type: Journal Article
Subjects: Animals
Female
Gastrins.physiology
Hepatectomy
Hepatocytes.physiology
Liver.metabolism.pathology.physiopathology
Liver Regeneration.physiology
Male
Mice
Mice, Inbred BALB C
Mice, Knockout
Organ Size
Appears in Collections:Journal articles

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