Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10494
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dc.contributor.authorHallam, Karen Ten
dc.contributor.authorBegg, Denovan Pen
dc.contributor.authorOlver, James Sen
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T23:57:27Z
dc.date.available2015-05-15T23:57:27Z
dc.date.issued2008-03-01en
dc.identifier.citationHuman Psychopharmacology; 23(2): 129-37en
dc.identifier.govdoc18172907en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10494en
dc.description.abstractThe secretion of the hormone melatonin is particularly robust to the effect of pharmacological agents. Medications may alter melatonin levels through either altering adrenergic activity or affecting liver enzymes involved in melatonin metabolism. The aim of this study was to investigate the effect of venlafaxine, a third generation antidepressant with known adrenergic properties on melatonin secretion. A further aim of the study was to investigate the correlation between plasma and salivary measures on this medication. Eight healthy adult participants (four males, four females) took part in this double blind placebo controlled randomised trial. Participants were tested on 3 nights after taking venlafaxine XR (75 mg), venlafaxine IR (75 mg) or placebo. Participants were placed in a darkened room between 1900 and 0300 h and regular temperature readings, blood and saliva samples were drawn to assess melatonin and cortisol secretion in each condition. There was no significant effect of venlafaxine IR or XR on melatonin concentrations in plasma or saliva and no effects on other circadian parameters including cortisol and temperature. It was notable that the correlation between plasma and salivary melatonin levels became poor after drug treatment. These results indicate that at low doses the mixed serotonergic and noradrenergic drug venlafaxine has no effect on nocturnal melatonin concentrations.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAntidepressive Agents, Second-Generation.administration & dosage.pharmacologyen
dc.subject.otherBody Temperature.drug effectsen
dc.subject.otherCircadian Rhythm.physiologyen
dc.subject.otherCyclohexanols.administration & dosage.pharmacologyen
dc.subject.otherDelayed-Action Preparationsen
dc.subject.otherDouble-Blind Methoden
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHydrocortisone.blood.secretionen
dc.subject.otherMaleen
dc.subject.otherMelatonin.blood.secretionen
dc.subject.otherSaliva.chemistryen
dc.subject.otherSerotonin Uptake Inhibitors.administration & dosage.pharmacologyen
dc.subject.otherTime Factorsen
dc.titleAn investigation of the effect of immediate and extended release venlafaxine on nocturnal melatonin and cortisol release in healthy adult volunteers.en
dc.typeJournal Articleen
dc.identifier.journaltitleHuman psychopharmacologyen
dc.identifier.affiliationDepartment of Psychiatry (Austin Health), The University of Melbourne, Australiaen
dc.identifier.doi10.1002/hup.913en
dc.description.pages129-37en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18172907en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptPsychiatry (University of Melbourne)-
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