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https://ahro.austin.org.au/austinjspui/handle/1/10487
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, K F | en |
dc.contributor.author | Zhuo, J L | en |
dc.contributor.author | Mendelsohn, Frederick AO | en |
dc.date.accessioned | 2015-05-15T23:56:54Z | |
dc.date.available | 2015-05-15T23:56:54Z | |
dc.date.issued | 1991-12-01 | en |
dc.identifier.citation | British Journal of Pharmacology; 104(4): 771-2 | en |
dc.identifier.govdoc | 1810594 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/10487 | en |
dc.description.abstract | The in vivo access of the nonpeptide angiotensin II (Ang II) antagonist, DuP 753 (10 mg kg-1, i.v.), to Ang II receptors of rat brain was investigated by in vitro autoradiography with [125I]-[Sar1, Ile8] Ang II as a ligand. DuP 753 markedly inhibited the binding to sites which contain exclusively AT1 receptors both outside and within the blood brain barrier, such as the circumventricular organs, paraventricular hypothalamic nucleus, median preoptic nucleus and nucleus of the solitary tract. However, binding to other nuclei containing AT2 receptors was not significantly inhibited. These results demonstrate that DuP 753 and/or its active metabolite readily cross the blood brain barrier in vivo and selectively inhibit binding to AT1 receptors in specific brain nuclei. | en |
dc.language.iso | en | en |
dc.subject.other | 1-Sarcosine-8-Isoleucine Angiotensin II.pharmacology | en |
dc.subject.other | Angiotensin II.antagonists & inhibitors | en |
dc.subject.other | Angiotensin Receptor Antagonists | en |
dc.subject.other | Animals | en |
dc.subject.other | Autoradiography | en |
dc.subject.other | Biphenyl Compounds.administration & dosage.pharmacology | en |
dc.subject.other | Brain Chemistry.drug effects | en |
dc.subject.other | Imidazoles.administration & dosage.pharmacology | en |
dc.subject.other | Iodine Radioisotopes.diagnostic use | en |
dc.subject.other | Losartan | en |
dc.subject.other | Male | en |
dc.subject.other | Medulla Oblongata.drug effects.physiology | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Inbred Strains | en |
dc.subject.other | Tetrazoles.administration & dosage.pharmacology | en |
dc.title | Access of peripherally administered DuP 753 to rat brain angiotensin II receptors. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | British journal of pharmacology | en |
dc.identifier.affiliation | Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australia | en |
dc.description.pages | 771-2 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/1810594 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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