Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10486
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSeeman, Egoen
dc.date.accessioned2015-05-15T23:56:50Z-
dc.date.available2015-05-15T23:56:50Z-
dc.date.issued2008-01-10en
dc.identifier.citationJournal of Bone and Mineral Metabolism 2008; 26(1): 1-8en
dc.identifier.govdoc18095057en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10486en
dc.description.abstractThe material composition and structural design of bone determine its strength. Structure determines loads that can be tolerated but loads also determine structure. Bone modifies its material composition and structure to accommodate loads by adaptive modeling and remodeling. Adaptation is successful during growth but not aging because accumulating insults, including a reduction in the volume of bone formed in the basic multicellular unit (BMU), increased resorption in the BMU, increased remodeling rate in midlife in women and in some men because of sex hormone deficiency, and in both sexes in old age as a consequence of secondary hyperparathyroidism and reduced periosteal bone formation, all of which compromises the material composition of bone and its structure. An understanding of the mechanisms of adaptation and failed adaptation provides rational approaches to interventions that can prevent or restore bone fragility.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgingen
dc.subject.otherAnimalsen
dc.subject.otherBone Densityen
dc.subject.otherBone Remodelingen
dc.subject.otherBone and Bones.anatomy & histology.physiologyen
dc.subject.otherFemaleen
dc.subject.otherFemur Neck.anatomy & histologyen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherSex Characteristicsen
dc.subject.otherSpine.growth & developmenten
dc.titleBone quality: the material and structural basis of bone strength.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of bone and mineral metabolismen
dc.identifier.affiliationDepartment of Endocrinology and Medicine, Austin Hospital, Austin Health, Heidelberg 3084, Melbourne, Australiaen
dc.identifier.doi10.1007/s00774-007-0793-5en
dc.description.pages1-8en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18095057en
Appears in Collections:Journal articles

Files in This Item:
File SizeFormat 
18095057.pdf49.38 kBAdobe PDFView/Open


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.