Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10465
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dc.contributor.authorHurley, J Cen
dc.contributor.authorLouis, William Jen
dc.contributor.authorTosolini, F Aen
dc.contributor.authorCarlin, J Ben
dc.date.accessioned2015-05-15T23:55:16Z
dc.date.available2015-05-15T23:55:16Z
dc.date.issued1991-11-01en
dc.identifier.citationAntimicrobial Agents and Chemotherapy; 35(11): 2388-94en
dc.identifier.govdoc1804012en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10465en
dc.description.abstractA novel in vivo model for the study of antibiotic-induced release of endotoxin from gram-negative bacteria is described. The model uses the chronically colonized urinary tracts of patients whose spinal cords have been injured. At baseline, the organisms were present in the range of 1 x 10(3) to 2 x 10(7) CFU/ml, and the concentration of endotoxin ranged from 2 x 10(-1) to 1 x 10(3) ng/ml in 44 studies. In 10 control studies, the concentration of endotoxin and the numbers of viable gram-negative bacteria over time changed by an average of less than 0.15 log10 units from the baseline values. At 2 h after antibiotic administration, the average decrease in CFU was 0.93 log10 units, and because antibiotics cause the release of endotoxin, an average increase in endotoxin concentration of 0.59 log10 units was noted in 21 studies with susceptible bacteria. Similar changes in response to antibiotic exposure were seen in studies with susceptible Pseudomonas bacteria in comparison with those seen in studies with susceptible members of the family Enterobacteriaceae. These results provide evidence that this novel model may be useful for comparing the effects of antibiotics with different modes of action, both as single agents and in combination, on the concentration of endotoxin in relation to changes in the numbers of bacteria, under conditions of bacterial replication and antibiotic exposure more closely resembling those found in vivo than is possible in other models.en
dc.language.isoenen
dc.subject.otherAnti-Bacterial Agents.pharmacologyen
dc.subject.otherBacteriuria.complications.metabolismen
dc.subject.otherChronic Diseaseen
dc.subject.otherCiprofloxacin.pharmacologyen
dc.subject.otherColony Count, Microbialen
dc.subject.otherEndotoxins.metabolismen
dc.subject.otherEnterobacteriaceae.drug effectsen
dc.subject.otherGentamicins.urineen
dc.subject.otherHumansen
dc.subject.otherLactamsen
dc.subject.otherLimulus Testen
dc.subject.otherModels, Biologicalen
dc.subject.otherPseudomonas.drug effectsen
dc.subject.otherSpinal Cord Injuries.complicationsen
dc.subject.otherUrinary Tract Infections.microbiologyen
dc.titleAntibiotic-induced release of endotoxin in chronically bacteriuric patients.en
dc.typeJournal Articleen
dc.identifier.journaltitleAntimicrobial agents and chemotherapyen
dc.identifier.affiliationDepartment of Clinical Pharmacology and Therapeutics, Austin Hospital, Heidelberg.en
dc.description.pages2388-94en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1804012en
dc.type.austinJournal Articleen
local.name.researcherLouis, William J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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