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dc.contributor.authorLouis, Simon N Sen
dc.contributor.authorWang, Linen
dc.contributor.authorChow, Laurie T Cen
dc.contributor.authorRezmann, Linda Adrianaen
dc.contributor.authorImamura, Keisakuen
dc.contributor.authorMacGregor, Duncan Pen
dc.contributor.authorCasely, Daviden
dc.contributor.authorCatt, Kevin Jen
dc.contributor.authorFrauman, Albert Gen
dc.contributor.authorLouis, William Jen
dc.identifier.citationCancer Detection and Prevention 2007; 31(5): 391-5en
dc.description.abstractDespite increasing interest in the renin-angiotensin system in cancer, little is known about angiotensin II (Ang II) expression in human prostate tumors.Using immunohistochemistry, we examined Ang II expression in prostate cancer (Gleason grades 2-5), benign prostatic hyperplasia (BPH), and high-grade prostatic intraepithelial neoplasia (HGPIN).Ang II was present in proliferating neoplastic cells in HGPIN, in malignant cells in all grades of prostate cancer examined, in basal but not luminal epithelial cells in BPH, and in the cytoplasm of LNCaP, DU145, and PC3 prostate cancer cells.The data establishes the presence of Ang II in pre-malignant and malignant prostate cells, suggests Ang II staining in non-basal epithelial cells is an early sign of malignant change, and supports suggestions that HGPIN and malignant prostate cells both arise from transformed basal cells. Using immunohistochemistry we examined Ang II expression in proliferative disorders of the prostate and concluded that Ang II staining in non-basal epithelial cells is evidence of early malignant change.en
dc.subject.otherAngiotensin II.biosynthesisen
dc.subject.otherBlotting, Westernen
dc.subject.otherCell Transformation, Neoplastic.metabolismen
dc.subject.otherEpithelial Cells.metabolism.pathologyen
dc.subject.otherProstatic Hyperplasia.metabolism.pathologyen
dc.subject.otherProstatic Intraepithelial Neoplasia.metabolism.pathologyen
dc.subject.otherProstatic Neoplasms.metabolism.pathologyen
dc.subject.otherTumor Markers, Biological.analysisen
dc.titleAppearance of angiotensin II expression in non-basal epithelial cells is an early feature of malignant change in human prostate.en
dc.typeJournal Articleen
dc.identifier.journaltitleCancer detection and preventionen
dc.identifier.affiliationClinical Pharmacology and Therapeutics Unit, University of Melbourne, Department of Medicine, Austin Health, Heidelberg, 3084 Vic., Australiaen
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