Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10442
Title: Hyperbaric oxygen therapy for severe acute pancreatitis.
Authors: Christophi, Christopher;Millar, Ian;Nikfarjam, Mehrdad;Muralidharan, Vijayaragavan;Malcontenti-Wilson, Caterina
Affiliation: Department of Surgery, University of Melbourne, Austin Hospital, Melbourne, Victoria, Australia. c.christophi@unimelb.edu.au
Issue Date: 1-Nov-2007
Citation: Journal of Gastroenterology and Hepatology; 22(11): 2042-6
Abstract: Despite improvements in the supportive management of severe acute pancreatitis over the last decade, the morbidity and mortality rate remains high. The main feature of this condition is pancreatic necrosis leading to sepsis, with both localized and systemic inflammatory response syndromes. Early pathophysiological changes of the pancreas include alterations in microcirculation, ischemia reperfusion injury, and leukocyte and cytokine activation. The efficacy of hyperbaric oxygen (HBO) therapy in improving these pathophysiological disturbances is documented for various conditions. However, its effect in the treatment of severe acute pancreatitis is undetermined. This report documents the case of a 56-year-old woman presenting with severe acute pancreatitis treated by HBO therapy. The severity of disease was based on an Acute Physiology and Chronic Health Evaluation (APACHE II) illness grading score of 11 and a Baltazar based computed tomography severity index (CTSI) score of 9. Administration of 100% oxygen was commenced within 72 h of presentation at a pressure of 2.5 atmospheres for 90 min and given twice daily for a total of 5 days. Therapy was well tolerated with improvements in APACHE II and CTSI grading scores. HBO therapy for severe acute pancreatitis appeared to be safe and may have a role in improving treatment outcomes. Further study is required.
Internal ID Number: 17914992
URI: http://ahro.austin.org.au/austinjspui/handle/1/10442
DOI: 10.1111/j.1440-1746.2006.03380.x
URL: http://www.ncbi.nlm.nih.gov/pubmed/17914992
Type: Journal Article
Subjects: APACHE
Acute Disease
Female
Humans
Hyperbaric Oxygenation
Middle Aged
Pancreatitis.radiography.therapy
Severity of Illness Index
Tomography, X-Ray Computed
Treatment Outcome
Appears in Collections:Journal articles

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