Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10401
Title: CCK receptors and cancer.
Authors: Baldwin, Graham S;Shulkes, Arthur
Affiliation: University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia
grahamsb@unimelb.edu.au
Issue Date: 2007
Citation: Current Topics in Medicinal Chemistry; 7(12): 1232-8
Abstract: Over the past 20 years there has been considerable interest in the role of CCK receptors in gastrointestinal cancer. Initial excitement over reports of the detection by PCR of CCK-1 and CCK-2 receptor mRNA in a wide range of gastrointestinal tumours has been tempered by the realisation that the presence of receptor binding sites is much more restricted. The current consensus is that expression of CCK-1 and -2 receptor proteins is common only in tumours of neural or neuroendocrine origin. A striking example of this general rule has been provided by the detection of CCK-2 receptors by receptor autoradiography in more than 90% of medullary thyroid carcinomas. Despite the absence of CCK receptors from many gastrointestinal adenocarcinomas, evidence from animal models and from tumour cell lines in vitro suggests that the CCK-2 receptor may contribute to the development of esophageal and gastric adenocarcinomas, and further experimental work in these areas is clearly warranted. Promising therapeutic approaches include the development of radiolabelled gastrin/CCK derivatives for use in tumour imaging, and the use of appropriate selective antagonists for treatment of those tumour subtypes likely to express CCK receptors.
Internal ID Number: 17584144
URI: http://ahro.austin.org.au/austinjspui/handle/1/10401
URL: http://www.ncbi.nlm.nih.gov/pubmed/17584144
Type: Journal Article
Subjects: Animals
Gastrointestinal Neoplasms.genetics.metabolism.pathology.therapy
Humans
Pancreatic Neoplasms.genetics.metabolism.pathology.therapy
Receptors, Cholecystokinin.chemistry.genetics.metabolism
Appears in Collections:Journal articles

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