Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLontos, Steveen
dc.contributor.authorGow, Paul Jen
dc.contributor.authorVaughan, Rhys Ben
dc.contributor.authorAngus, Peter Wen
dc.identifier.citationJournal of Gastroenterology and Hepatology 2007; 23(2): 252-5en
dc.description.abstractAlthough norfloxacin (N) is widely accepted as the drug of choice for spontaneous bacterial peritonitis (SBP) prophylaxis, there is data to suggest that trimethoprim-sulfamethoxazole (TS) may be similarly effective. However, no studies have compared the efficacy and safety of N and TS in SBP prophylaxis. The aim of this retrospective analysis was to compare outcomes in patients who received either N or TS for the prevention of SBP.Records of all cirrhotic patients prescribed either N or TS for SBP prevention between April 2001 and May 2004 were reviewed. Data collected included age, sex, Child-Pugh score, ascitic protein concentration, etiology of liver disease, infections (SBP, bacteremia, and extraperitoneal infections), side-effects, and survival.Sixty-nine patients (18 female, 51 male), mean age 53.9 +/- 10.6 years, were prescribed N (n = 37) or TS (n = 32). The Child-Pugh score, model for end-stage liver disease score, and the prevalence of a low ascitic protein (<15 g/L) were similar between the groups (12.0 vs 12.4, 19.7 vs 18.2, and 78% vs 84%, respectively, P > 0.05). Fourteen (38%) infections occurred in the N group and 16 (50%) in the TS group (P > 0.05). Eight patients (21.6%) in the N group and nine (28%) in the TS group developed SBP (P > 0.05). The rates of liver transplantation (10 vs 13), adverse events (two in each group) and death (13 vs 14) were similar in the two treatment groups.Our findings suggest N and TS have similar efficacy in preventing SBP. This has significant implications for both the cost of SBP prophylaxis and the prevalence of fluoroquinolone resistance in patients with cirrhosis.en
dc.subject.otherAnti-Bacterial Agents.adverse effects.therapeutic useen
dc.subject.otherAnti-Infective Agents.adverse effects.therapeutic useen
dc.subject.otherBacterial Infectionsen
dc.subject.otherMiddle Ageden
dc.subject.otherNorfloxacin.adverse effects.therapeutic useen
dc.subject.otherPeritonitis.microbiology.mortality.prevention & controlen
dc.subject.otherRetrospective Studiesen
dc.subject.otherTreatment Outcomeen
dc.subject.otherTrimethoprim-Sulfamethoxazole Combination.adverse effects.therapeutic useen
dc.titleNorfloxacin and trimethoprim-sulfamethoxazole therapy have similar efficacy in prevention of spontaneous bacterial peritonitis.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Gastroenterology and Hepatologyen
dc.identifier.affiliationDepartment of Gastroenterology and Hepatology, Austin Health, Melbourne, Australiaen
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.

Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.