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Title: Fluid resuscitation and the septic kidney: the evidence.
Authors: Licari, Elisa;Calzavacca, Paolo;Ronco, Claudio;Bellomo, Rinaldo
Affiliation: Department of Intensive Care, Austin Hospital, Melbourne, Vic., Australia
Issue Date: 2007
Citation: Contributions To Nephrology; 156(): 167-77
Abstract: Acute kidney injury (AKI) is a common complication of severe sepsis. Severe sepsis is the most common cause of AKI in ICU. The widely accepted and practiced initial cornerstone of treatment for septic AKI is fluid resuscitation. The biological rationale for fluid resuscitation in septic AKI is based on the assumption that septic AKI is an ischemic form of AKI and that increasing renal perfusion and oxygen delivery by means of fluid resuscitation will protect the kidney. Whether this is true, however, remains uncertain. In this paper, we discuss salient pathophysiological aspects of AKI, review the evidence available on the need for fluid resuscitation, the amount and the type of fluid that might be best suited to AKI and discuss all major aspects of fluid resuscitation for septic AKI in humans and experimental animals.
Internal ID Number: 17464124
DOI: 10.1159/0000102080
Type: Journal Article
Subjects: Acute Kidney Injury.etiology.microbiology.therapy
Critical Care.methods
Disease Models, Animal
Fluid Therapy.methods
Kidney.blood supply.physiopathology
Regional Blood Flow.physiology
Appears in Collections:Journal articles

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