Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10365
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dc.contributor.authorHaase-Fielitz, Anjaen
dc.contributor.authorHaase, Michaelen
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorDragun, Duskaen
dc.date.accessioned2015-05-15T23:47:41Z
dc.date.available2015-05-15T23:47:41Z
dc.date.issued2007en
dc.identifier.citationContributions To Nephrology; 156(): 75-91en
dc.identifier.govdoc17464117en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10365en
dc.description.abstractAcute kidney injury (AKI) is a major medical problem in critical illness, and has a separate independent effect on the risk of death. Septic shock and cardiac surgery utilizing cardiopulmonary bypass are the two most common factors contributing to AKI. Clinical predictors and biochemical markers identified for the development of AKI can only explain a part of this individual risk. Another tool to predict the risk of AKI and to improve individualized patient care focuses on the identification of genetic risk factors which might be involved in the development of AKI. However, to date our knowledge on the importance of such genetic polymorphisms in influencing the susceptibility to and severity of AKI remains limited. There is evidence that several genetic polymorphisms accounting for sepsis- or cardiopulmonary bypass-associated AKI involve genes which participate in the control of inflammatory or vasomotor processes. In this article, we will review current knowledge concerning the role of genetic polymorphism in the pathogenesis of sepsis- and cardiopulmonary bypass-associated AKI and discuss possible areas for future developments and research in this field.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.etiology.geneticsen
dc.subject.otherApolipoproteins E.geneticsen
dc.subject.otherCardiopulmonary Bypass.adverse effectsen
dc.subject.otherGenetic Predisposition to Diseaseen
dc.subject.otherHumansen
dc.subject.otherInterleukin-10.geneticsen
dc.subject.otherInterleukin-6.geneticsen
dc.subject.otherPolymorphism, Single Nucleotideen
dc.subject.otherRisk Factorsen
dc.subject.otherSepsis.complicationsen
dc.subject.otherSeverity of Illness Indexen
dc.subject.otherTumor Necrosis Factor-alpha.geneticsen
dc.titleGenetic polymorphisms in sepsis- and cardiopulmonary bypass-associated acute kidney injury.en
dc.typeJournal Articleen
dc.identifier.journaltitleContributions to nephrologyen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1159/0000102072en
dc.description.pages75-91en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17464117en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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