Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10318
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dc.contributor.authorFarouque, Omaren
dc.contributor.authorMeredith, Ian Ten
dc.date.accessioned2015-05-15T23:44:03Z
dc.date.available2015-05-15T23:44:03Z
dc.date.issued2007-02-01en
dc.identifier.citationTrends in Cardiovascular Medicine; 17(2): 63-8en
dc.identifier.govdoc17292049en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10318en
dc.description.abstractThe ATP-sensitive potassium (K(ATP)) channel is a distinct type of potassium ion channel that is found in the vascular smooth muscle cells of a variety of mammalian species, including humans. The activity of K(ATP) channels is determined by many factors including cellular ATP and ADP levels, thus providing a link between cellular metabolism and vascular tone through its effects on membrane potential. Experimental studies using inhibitors of K(ATP) channels, such as the sulfonuylurea class of drugs, indicate that these channels modulate coronary vascular tone including the hyperaemia induced by increased myocardial metabolism. This review examines the evidence linking K(ATP) channels to the regulation of coronary vascular tone and the potential clinical implications of pharmacologic therapies that act on K(ATP) channels.en
dc.language.isoenen
dc.subject.otherAdenosine Triphosphate.physiologyen
dc.subject.otherAnimalsen
dc.subject.otherCoronary Disease.drug therapy.physiopathologyen
dc.subject.otherCoronary Vessels.drug effects.physiology.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherMuscle, Smooth, Vascular.drug effects.physiologyen
dc.subject.otherPotassium Channel Blockers.pharmacologyen
dc.subject.otherPotassium Channels.physiologyen
dc.subject.otherVasodilation.drug effects.physiologyen
dc.titleEffect of adenosine triphosphate-sensitive potassium channel inhibitors on coronary metabolic vasodilation.en
dc.typeJournal Articleen
dc.identifier.journaltitleTrends in cardiovascular medicineen
dc.identifier.affiliationDepartment of Cardiology, Austin Health, Heidelberg, Victoria, 3084, Australiaen
dc.identifier.doi10.1016/j.tcm.2006.12.003en
dc.description.pages63-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17292049en
dc.type.austinJournal Articleen
local.name.researcherFarouque, Omar
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
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