Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10308
Title: Liver regeneration stimulates tumor metastases.
Authors: Harun, Nadia;Nikfarjam, Mehrdad;Muralidharan, Vijayaragavan;Christophi, Christopher
Affiliation: Department of Surgery, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia. n.harun1@pgrad.unimelb.edu.au
Issue Date: 24-Jan-2007
Citation: The Journal of Surgical Research 2007; 138(2): 284-90
Abstract: Partial hepatectomy for patients with colorectal liver metastases is associated with a tumor recurrence rate approaching 80% post-resection. Different factors and phases associated with regeneration of the liver are implicated in tumor recurrence. This study investigates the effects of the early and late phases of liver regeneration and the impact of the degree of liver resection on stimulating tumor growth and metastasis.Groups of mice underwent partial hepatectomy (37% or 70%) and were then challenged with colorectal liver carcinoma (CRC) tumors immediately after liver resection (early and late phase effect) or 6 days post liver resection (late phase effect). Tumor growth, degree of proliferation, tumor morphology, and the presence of extrahepatic metastases were investigated 21 days post-tumor induction.The late phase of liver regeneration plays a significant role in tumor stimulation and metastasis. The degree of hepatectomy also appears to be an important factor. The degree of hepatic resection significantly influences tumor growth and the extent of extrahepatic metastases, particularly in the lungs.Elucidation of the processes involved in the late phase of liver regeneration may assist in the development and timing of adjuvant agents to minimize tumor recurrence during this phase.
Internal ID Number: 17254608
URI: http://ahro.austin.org.au/austinjspui/handle/1/10308
DOI: 10.1016/j.jss.2006.06.024
URL: http://www.ncbi.nlm.nih.gov/pubmed/17254608
Type: Journal Article
Subjects: Animals
Cell Division
Cell Line, Tumor
Colorectal Neoplasms.pathology
Disease Models, Animal
Hepatectomy
Liver.pathology.surgery
Liver Neoplasms.secondary.surgery
Liver Regeneration
Male
Mice
Mice, Inbred CBA
Neoplasm Recurrence, Local.pathology
Neoplasm Transplantation
Postoperative Complications.pathology
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.