Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10280
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dc.contributor.authorCherk, Martin Hen
dc.contributor.authorFoo, Serene Sen
dc.contributor.authorPoon, Aurora M Ten
dc.contributor.authorKnight, Simon Ren
dc.contributor.authorMurone, Carmelen
dc.contributor.authorPapenfuss, Anthony Ten
dc.contributor.authorSachinidis, John Ien
dc.contributor.authorSaunder, Timothy H Cen
dc.contributor.authorO'Keefe, Graeme Jen
dc.contributor.authorScott, Andrew Men
dc.date.accessioned2015-05-15T23:41:10Z
dc.date.available2015-05-15T23:41:10Z
dc.date.issued2006-12-01en
dc.identifier.citationJournal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine; 47(12): 1921-6en
dc.identifier.govdoc17138734en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10280en
dc.description.abstractPET offers a noninvasive means to assess neoplasms, in view of its sensitivity and accuracy in staging tumors and potentially in monitoring treatment response. The aim of this study was to evaluate newly diagnosed non-small cell lung cancer (NSCLC) for the presence of hypoxia, as indicated by the uptake of (18)F-Fluoromisonidazole ((18)F-FMISO), and to examine the relationship of hypoxia to the uptake of (18)F-FDG, microvessel density, and other molecular markers of hypoxia.Twenty-one patients with suspected or biopsy-proven NSCLC were enrolled prospectively in this study. All patients had PET studies with (18)F-FMISO and (18)F-FDG. Seventeen patients subsequently underwent surgery, with analysis performed for tumor markers of angiogenesis and hypoxia.In the 17 patients with resectable NSCLC (13 men, 4 women; age range, 51-77 y), the mean (18)F-FMISO uptake in tumor was significantly lower than that of (18)F-FDG uptake (P < 0.0001) and showed no correlation with (18)F-FDG uptake (r = 0.26). The mean (95% confidence interval [CI]) (18)F-FMISO SUV(max) (maximum standardized uptake value) was 1.20 [0.95-1.45] compared with the mean [95% CI] (18)F-FDG SUV(max) of 5.99 [4.62-7.35]. The correlation between (18)F-FMISO uptake, (18)F-FDG uptake, and tumor markers of hypoxia and angiogenesis was poor. A weakly positive correlation between (18)F-FMISO and (18)F-FDG uptake and Ki67 was found.The hypoxic cell fraction of primary NSCLC is consistently low, and there is no significant correlation in NSCLC between hypoxia and glucose metabolism in NSCLC assessed by (18)F-FDG. These findings have direct implications in understanding the role of angiogenesis and hypoxia in NSCLC biology.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherCarcinoma, Non-Small-Cell Lung.metabolism.radionuclide imagingen
dc.subject.otherCell Hypoxiaen
dc.subject.otherFluorodeoxyglucose F18.diagnostic use.pharmacokineticsen
dc.subject.otherGlucose.metabolismen
dc.subject.otherHumansen
dc.subject.otherLung Neoplasms.metabolism.radionuclide imagingen
dc.subject.otherMaleen
dc.subject.otherMetabolic Clearance Rateen
dc.subject.otherMiddle Ageden
dc.subject.otherMisonidazole.analogs & derivatives.diagnostic use.pharmacokineticsen
dc.subject.otherNeovascularization, Pathologic.metabolism.radionuclide imagingen
dc.subject.otherRadiopharmaceuticals.diagnostic use.pharmacokineticsen
dc.subject.otherStatistics as Topicen
dc.titleLack of correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in non-small cell lung cancer assessed by 18F-Fluoromisonidazole and 18F-FDG PET.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Nuclear Medicineen
dc.identifier.affiliationCentre for PET, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages1921-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17138734en
dc.type.austinJournal Articleen
local.name.researcherKnight, Simon R
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThoracic Surgery-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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