Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10259
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dc.contributor.authorWee, Janet L Ken
dc.contributor.authorJackson, Denise Een
dc.date.accessioned2015-05-15T23:39:06Z
dc.date.available2015-05-15T23:39:06Z
dc.date.issued2006-10-01en
dc.identifier.citationCurrent Drug Targets; 7(10): 1265-73en
dc.identifier.govdoc17073587en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10259en
dc.description.abstractPlatelet activation is crucial for normal hemostasis to arrest bleeding following vascular injury. However, excessive platelet activation in narrowed atherosclerotic blood vessels that are subject to high shear forces may initiate the onset of arterial thrombosis. When platelets come into contact with, and adhere to collagen exposed by damaged endothelium, they undergo morphological and functional changes necessary to generate a platelet-rich thrombus. This process is complex and involves precise co-ordination of various signaling pathways which lead to firm platelet adhesion to sites of tissue damage, release of granule contents from activated platelets, platelet shape change, platelet aggregation and subsequent thrombus formation and consolidation. Induction of tyrosine phosphorylation of key signaling molecules has emerged as a critical event central to stimulatory signaling pathways that generate platelet activation, but is an essential component associated with regulatory pathways that limit the extent of platelet activation. Understanding mechanisms that regulate platelet activation may contribute to the development of novel therapeutics that control common vascular diseases such as myocardial infarction and ischaemic stroke.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Platelets.drug effects.metabolism.physiologyen
dc.subject.otherHumansen
dc.subject.otherPhosphotyrosine.physiologyen
dc.subject.otherPlatelet Activation.drug effects.physiologyen
dc.subject.otherSignal Transduction.drug effects.physiologyen
dc.subject.otherThrombosis.drug therapy.metabolismen
dc.titlePhosphotyrosine signaling in platelets: lessons for vascular thrombosis.en
dc.typeJournal Articleen
dc.identifier.journaltitleCurrent drug targetsen
dc.identifier.affiliationAustin Research Institute, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.description.pages1265-73en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17073587en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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