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|Title:||Increase in galanin and neuropeptide Y mRNA in locus coeruleus following acute reserpine treatment.|
|Authors:||Gundlach, Andrew L;Rutherfurd, S D;Louis, William J|
|Affiliation:||University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.|
|Citation:||European Journal of Pharmacology; 184(1): 163-7|
|Abstract:||Galanin and neuropeptide Y are known to coexist with noradrenaline in neurones of the locus coeruleus. Furthermore, reserpine depletes noradrenaline from, and increases the synthesis and activity of the catecholamine-synthesizing enzyme tyrosine hydroxylase in, this nucleus. We have found by in situ hybridization of specific 35S-labelled oligonucleotide probes that a single dose of reserpine (10 mg/kg) induced a significant (70-145%) and long-lasting (up to at least 3 days) increase in the amount of galanin and neuropeptide Y mRNA in the locus coeruleus (along with the characteristic increase in tyrosine hydroxylase mRNA). These results suggest a similar reserpine-sensitive mechanism of galanin, neuropeptide Y and tyrosine hydroxylase gene regulation.|
|Internal ID Number:||1698642|
Locus Coeruleus.drug effects.metabolism
Nucleic Acid Hybridization
Rats, Inbred Strains
|Appears in Collections:||Journal articles|
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