Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10211
Title: Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin.
Authors: McIntyre, I M;Norman, Trevor R
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 16-May-1990
Citation: Journal of Neural Transmission. General Section; 79(1-2): 35-40
Abstract: A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. A single dose of isatin significantly increased 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations. Synaptosomal 5-HT uptake was unaffected but there was a trend for the number of 3H-ketanserin binding sites was to be decreased. The results of the study are discussed in terms of the relationship of isatin to tribulin and their possible causal role in stress.
Internal ID Number: 1688707
URI: http://ahro.austin.org.au/austinjspui/handle/1/10211
URL: http://www.ncbi.nlm.nih.gov/pubmed/1688707
Type: Journal Article
Subjects: Animals
Cerebral Cortex.drug effects.metabolism
Hydroxyindoleacetic Acid.metabolism
Hypothalamus.drug effects.metabolism
Indoles.pharmacology
Isatin.pharmacology
Ketanserin.metabolism
Male
Monoamine Oxidase Inhibitors.metabolism.pharmacology
Rats
Rats, Inbred Strains
Serotonin.metabolism.pharmacokinetics
Synaptosomes.metabolism
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.