Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10204
Title: Invasive squamous cell carcinoma after treatment of carcinoma in situ with 5% imiquimod cream.
Authors: Goh, Michelle S Y
Affiliation: Department of Dermatology, Austin Hospital, Heidelberg, Victoria, Australia. M.Goh@alfred.org.au
Issue Date: 1-Aug-2006
Citation: The Australasian Journal of Dermatology; 47(3): 186-8
Abstract: Squamous cell carcinoma in situ has the potential to progress to invasive squamous cell carcinoma. This report presents two cases of punch biopsy-proven squamous cell carcinoma in situ, treated with once-daily application of 5% imiquimod cream for 6 weeks. Both patients developed moderate local inflammatory reactions during treatment. The first patient demonstrated clinical clearance of the scalp lesion after treatment. Two months later, he re-presented with a subcutaneous nodule at the same site. Histology was consistent with recurrent squamous cell carcinoma. Five months following excision of the recurrent tumour, he presented with metastatic squamous cell carcinoma to a cervical lymph node. The second patient had low-grade chronic lymphocytic leukaemia and presented with squamous cell carcinoma in situ of the leg that failed to clear clinically after treatment with imiquimod. He presented 4 months later with a focus of invasive squamous cell carcinoma within the lesion.
Internal ID Number: 16867000
URI: http://ahro.austin.org.au/austinjspui/handle/1/10204
DOI: 10.1111/j.1440-0960.2006.00269.x
URL: http://www.ncbi.nlm.nih.gov/pubmed/16867000
Type: Journal Article
Subjects: Administration, Topical
Aged, 80 and over
Aminoquinolines.administration & dosage
Antineoplastic Agents.administration & dosage
Carcinoma in Situ.diagnosis.drug therapy
Carcinoma, Squamous Cell.diagnosis.drug therapy.surgery
Disease Progression
Head and Neck Neoplasms.diagnosis.drug therapy.surgery
Humans
Leg
Lymph Node Excision
Lymphatic Metastasis
Male
Middle Aged
Neoplasms, Second Primary.diagnosis.surgery
Scalp
Skin Neoplasms.diagnosis.drug therapy.surgery
Treatment Outcome
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.