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|Title:||Febrile seizures: traffic slows in the heat.|
|Authors:||Berkovic, Samuel F;Petrou, Steven|
Department of Medicine and Epilepsy Research Centre, University of Melbourne, Austin Health, Heidelberg West, Victoria 3081, Australia
|Citation:||Trends in Molecular Medicine 2006; 12(8): 343-4|
|Abstract:||Febrile seizures, which occur in young children, have long been known to have a major inherited component. Mutations in some genes that encode sodium channel and GABA(A) receptor subunits have been found in a few families affected by febrile seizures. These mutations account only for a minority of cases, and much remains to be learnt about the molecular architecture of febrile seizures. A rare inherited cause--a mutation in the GABA(A) receptor subunit GABRG2 gene--has been recently shown to cause a temperature-dependent intracellular trafficking defect. This is an important step in unravelling the molecular pathogenesis of this common childhood disorder.|
|Internal ID Number:||16829199|
|Appears in Collections:||Journal articles|
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