Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10186
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dc.contributor.authorCincotta, Men
dc.contributor.authorYoung, N Aen
dc.contributor.authorBeart, P Men
dc.date.accessioned2015-05-15T23:33:26Z
dc.date.available2015-05-15T23:33:26Z
dc.date.issued1991-05-16en
dc.identifier.citationExperimental Brain Research; 85(3): 650-8en
dc.identifier.govdoc1680740en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10186en
dc.description.abstractQuantitative autoradiography was used to examine central binding sites for L-[3H]glutamate in amygdaloid-kindled rats since receptors for excitatory amino acids have been implicated in epileptiform activity and seizure behaviors. In tissue from rats killed five days after two kindled seizures, the ipsilateral hippocampus, entorhinal, perirhinal and parietal cortices had significantly (35-100%) greater densities of binding sites for L-[3H]glutamate than the opposite, contralateral side or operated, unstimulated controls. These regions receive excitatory inputs from the amygdala via the entorhinal cortex. Dissociation constants were not altered and significant differences were not observed in the binding parameters for L-[3H]glutamate between control and kindled rats or ipsilateral and contralateral sides of the amygdala, corpus striatum, nucleus accumbens or substantia nigra. The proportion and affinity of N-methyl-D-aspartate (NMDA)-sensitive binding sites for L-[3H]glutamate was unchanged after kindling, as were the relative proportions of kainate- and AMPA-(DL-alpha-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid) sensitive sites. However, the density of NMDA and non-NMDA receptor subtypes was increased in the ipsilateral hippocampus, entorhinal, perirhinal and parietal cortices of kindled rats. These findings of specific, unilateral glutamate receptor up-regulation may indicate adaptive responses to the enhanced excitation found in kindling, and are consistent with other neuronal changes reported in early kindling.en
dc.language.isoenen
dc.subject.otherAmygdala.chemistry.physiologyen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherGlutamates.metabolismen
dc.subject.otherGlutamic Aciden
dc.subject.otherHippocampus.physiologyen
dc.subject.otherKindling, Neurologic.physiologyen
dc.subject.otherMaleen
dc.subject.otherN-Methylaspartate.pharmacologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Glutamateen
dc.subject.otherReceptors, N-Methyl-D-Aspartate.analysisen
dc.subject.otherReceptors, Neurotransmitter.drug effectsen
dc.subject.otherUp-Regulationen
dc.titleUnilateral up-regulation of glutamate receptors in limbic regions of amygdaloid-kindled rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleExperimental Brain Researchen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages650-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1680740en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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