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Title: Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods.
Authors: Macisaac, Richard J;Tsalamandris, Con;Thomas, Merlin C;Premaratne, Erosha;Panagiotopoulos, Sianna;Smith, T J;Poon, A;Jenkins, Margaret A;Ratnaike, S I;Power, David Anthony;Jerums, George
Affiliation: Endocrine Centre and the Department of Medicine, Austin Health and University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg West, VIC, Australia
Issue Date: 3-May-2006
Citation: Diabetologia 2006; 49(7): 1686-9
Abstract: We compared the predictive performance of a GFR based on serum cystatin C levels with commonly used creatinine-based methods in subjects with diabetes.In a cross-sectional study of 251 consecutive clinic patients, the mean reference (plasma clearance of (99m)Tc-diethylene-triamine-penta-acetic acid) GFR (iGFR) was 88+/-2 ml min(-1) 1.73 m(-2). A regression equation describing the relationship between iGFR and 1/cystatin C levels was derived from a test population (n=125) to allow for the estimation of GFR by cystatin C (eGFR-cystatin C). The predictive performance of eGFR-cystatin C, the Modification of Diet in Renal Disease 4 variable formula (MDRD-4) and Cockcroft-Gault (C-G) formulas were then compared in a validation population (n=126).There was no difference in renal function (ml min(-1) 1.73 m(-2)) as measured by iGFR (89.2+/-3.0), eGFR-cystatin C (86.8+/-2.5), MDRD-4 (87.0+/-2.8) or C-G (92.3+/-3.5). All three estimates of renal function had similar precision and accuracy.Estimates of GFR based solely on serum cystatin C levels had the same predictive potential when compared with the MDRD-4 and C-G formulas.
Internal ID Number: 16752187
DOI: 10.1007/s00125-006-0275-7
ORCID: 0000-0002-0845-0001
Type: Journal Article
Subjects: Adult
Aged, 80 and over
Cross-Sectional Studies
Cystatin C
Glomerular Filtration Rate
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Appears in Collections:Journal articles

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