Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10147
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dc.contributor.authorRead, D Men
dc.contributor.authorShulkes, Arthuren
dc.contributor.authorFernley, Ren
dc.contributor.authorSimpson, Ren
dc.date.accessioned2015-05-15T23:30:23Z
dc.date.available2015-05-15T23:30:23Z
dc.date.issued1991-07-08en
dc.identifier.citationPeptides; 12(4): 887-92en
dc.identifier.govdoc1664950en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10147en
dc.description.abstractNeurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by HPLC analysis and by testing stability in plasma in vitro. These methods confirmed that the tumor NTLI was identical to NT(6-13). Since the metabolic clearance rate of synthetic NT(6-13) in sheep was 30-fold higher than NT(1-13), it suggests that the elevated plasma levels are the result of impaired clearance and/or markedly elevated production.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAmino Acid Sequenceen
dc.subject.otherAnimalsen
dc.subject.otherCarcinoma, Hepatocellular.chemistryen
dc.subject.otherChromatography, High Pressure Liquiden
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherLiver Neoplasms.chemistryen
dc.subject.otherMolecular Sequence Dataen
dc.subject.otherNeuropeptides.blood.chemistry.isolation & purificationen
dc.subject.otherRadioimmunoassayen
dc.subject.otherSheepen
dc.titleCharacterization of neurotensin(6-13) from an hepatic fibrolamellar carcinoma.en
dc.typeJournal Articleen
dc.identifier.journaltitlePeptidesen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin Hospital, Victoria, Australiaen
dc.description.pages887-92en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/1664950en
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