Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10131
Title: Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.
Authors: Bishop, Emma;Melvani, Sharmila;Howden, Benjamin P;Charles, Patrick G P;Grayson, M Lindsay
Affiliation: Infectious Diseases Department, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia. Emma.Bishop@austin.org.au
Issue Date: 1-Apr-2006
Citation: Antimicrobial Agents and Chemotherapy; 50(4): 1599-602
Abstract: We assessed the toxicity and clinical outcomes associated with linezolid therapy (mean duration, 29+/-28 days; range, 8 to 185 days) in 44 patients with serious gram-positive infections. Although a clinical cure was achieved in 73% of the cases, 28/44 (64%) had adverse reactions (thrombocytopenia, n=13; anemia, n=7; gastrointestinal, n=12; peripheral neuropathy, n=1; serotonin syndrome, n=1), such that a systematic monitoring protocol was developed.
Internal ID Number: 16569895
URI: http://ahro.austin.org.au/austinjspui/handle/1/10131
DOI: 10.1128/AAC.50.4.1599-1602.2006
URL: http://www.ncbi.nlm.nih.gov/pubmed/16569895
Type: Journal Article
Subjects: Acetamides.adverse effects
Adult
Aged
Aged, 80 and over
Anti-Infective Agents.adverse effects
Gram-Positive Bacterial Infections.drug therapy
Humans
Middle Aged
Oxazolidinones.adverse effects
Retrospective Studies
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.