Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10075
Title: Optimized clinical T2 relaxometry with a standard CPMG sequence.
Authors: Pell, Gaby S;Briellmann, Regula S;Waites, Anthony B;Abbott, David F;Lewis, David P;Jackson, Graeme D
Affiliation: Brain Research Institute, Austin Health, Heidelberg West, VIC, Australia.
Issue Date: 1-Feb-2006
Citation: Journal of Magnetic Resonance Imaging : Jmri; 23(2): 248-52
Abstract: To optimize the accuracy and precision of T2 measurements using the standard Carr-Purcell-Meiboom-Gill (CPMG) sequence. T2 values obtained with this technique are normally sensitive to imperfect refocusing due to the formation of unwanted stimulated echoes.Modifications are made to the refocusing slice selection width and the interleaving scheme. A widened refocusing slice improves the uniformity of the refocusing flip angle across the slice. A slow spin echo acquisition provided "gold standard" T2 values. Repeated T2 measurements in phantom and human studies are used to compare the accuracy and precision of the optimized and non-optimized CPMG implementations.The required slice thickness ratio between refocusing and excitation slice widths is found to be 3:1 for typical optimized radiofrequency pulses. T2 values obtained using this optimized implementation more closely correspond to "gold standard" values. Repeated T2 measurements indicate significantly improved correspondence between data and model. A reduction in the fitting error of approximately 70% is demonstrated for phantoms.We demonstrate that a relatively simple change to the CPMG relaxometry sequence parameters from the default setup yields significant improvements in the accuracy and precision of T2 measurements.
Internal ID Number: 16416434
URI: http://ahro.austin.org.au/austinjspui/handle/1/10075
DOI: 10.1002/jmri.20490
URL: http://www.ncbi.nlm.nih.gov/pubmed/16416434
Type: Journal Article
Subjects: Adult
Artifacts
Electron Spin Resonance Spectroscopy
Female
Humans
Magnetic Resonance Imaging.instrumentation.methods
Male
Middle Aged
Phantoms, Imaging
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Software Validation
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.