Effect of voxel size when calculating patient specific radionuclide dosimetry estimates using direct Monte Carlo simulation
- Kevin J. Hickson,
- Graeme J. O’Keefe
- … show all 2 hide
Rent the article at a discount
Rent now* Final gross prices may vary according to local VAT.
Get AccessAbstract
The scalable XCAT voxelised phantom was used with the GATE Monte Carlo toolkit to investigate the effect of voxel size on dosimetry estimates of internally distributed radionuclide calculated using direct Monte Carlo simulation. A uniformly distributed Fluorine-18 source was simulated in the Kidneys of the XCAT phantom with the organ self dose (kidney ← kidney) and organ cross dose (liver ← kidney) being calculated for a number of organ and voxel sizes. Patient specific dose factors (DF) from a clinically acquired FDG PET/CT study have also been calculated for kidney self dose and liver ← kidney cross dose. Using the XCAT phantom it was found that significantly small voxel sizes are required to achieve accurate calculation of organ self dose. It has also been used to show that a voxel size of 2 mm or less is suitable for accurate calculations of organ cross dose. To compensate for insufficient voxel sampling a correction factor is proposed. This correction factor is applied to the patient specific dose factors calculated with the native voxel size of the PET/CT study.
- Denis-Bacelar, AM, Romanchikova, M, Chittenden, S, Saran, FH, Mandeville, H, Du, Y, Flux, GD (2013) Patient-specific dosimetry for intracavitary 32p-chromic phosphate colloid therapy of cystic brain tumours. Eur J Nucl Med Mol Imag 40: pp. 1532-1541 CrossRef
- Zankl, M, Petoussi-Henss, N, Fill, U, Regulla, D (2003) The application of voxel phantoms to the internal dosimetry of radionuclides. Radiat Protect Dosim 105: pp. 539 CrossRef
- Segars, W, Tsui, B (2009) Mcat to xcat: the evolution of 4-d computerized phantoms for imaging research. Proc IEEE 97: pp. 1954-1968 CrossRef
- Piegl, L (1991) On nurbs: a survey. Comput Graph Appl 11: pp. 55-71 CrossRef
- Stabin, M, Sparks, R, Crowe, E (2005) Olinda/exm: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 46: pp. 1023
- Jan, S, Santin, G, Strul, D, Staelens, S, Assié, K, Autret, D, Avner, S, Barbier, R, Bardiès, M, Bloomfield, PM (2004) Gate: a simulation toolkit for pet and spect. Phys Med Biol 49: pp. 4543-4561 CrossRef
- Agostinelli, S, Allison, J, Amako, K, Apostolakis, J, Araujo, H, Arce, P, Asai, M, Axen, D, Banerjee, S, Barrand, G (2003) Geant4-a simulation toolkit. Nucl Instrum Method Phys Res Sect A 506: pp. 250-303 CrossRef
- Jan S, Santin G, Strul D, Staelens S, Assié K, Autret D, Avner S, Barbier R, Bardiès M, Bloomfield PM, et al. (2007) GATE users guide. http://www.opengatecollaboration.org
- Loevinger, R, Budinger, T, Watson, E (1988) Mird primer for absorbed dose calculations. The Society of Nuclear Medicine, New York
- Stabin, M, Siegel, J, Sparks, R, Eckerman, K, Breitz, H (2001) Contribution to red marrow absorbed dose from total body activity: a correction to the Mird method. J Nucl Med 42: pp. 492
- Williams, L, Liu, A, Yamauchi, D, Lopatin, G, Raubitschek, A, Wong, J (2002) The two types of correction of absorbed dose estimates for internal emitters. Cancer 94: pp. 1231-1234 CrossRef
- Howell, R, Wessels, B, Loevinger, R, Watson, E, Bolch, W, Brill, A, Charkes, N, Fisher, D, Hays, M, Robertson, J (1999) The Mird perspective 1999. Medical internal radiation dose committee. J Nucl Med 40: pp. 3S-10S
- Cloutier, RJ, Edwards, CL, Snyder, WS (1970) Medical radionuclides: radiation dose and effects. J Radiat Biol 18: pp. 399
- Browne, J, Pierro, A (1996) A row-action alternative to the em algorithm for maximizing likelihood in emission tomography. IEEE Trans Med Imag 15: pp. 687-699 CrossRef
- Saunder T (2006) Wasabi, medical image quantitative analysis and visualisation package. http://wasabi.petnm.unimelb.edu.au/index.html
- Snyder W, Ford M, Warner G, Watson S (1975) S”: absorbed dose per unit cumulated activity for selected radionuclides and organs. Mird pamphlet no. 11. Society of Nuclear Medicine, New York
- Stabin, M (1996) Mirdose: personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 37: pp. 538
- Title
- Effect of voxel size when calculating patient specific radionuclide dosimetry estimates using direct Monte Carlo simulation
- Journal
-
Australasian Physical & Engineering Sciences in Medicine
Volume 37, Issue 3 , pp 495-503
- Cover Date
- 2014-09-01
- DOI
- 10.1007/s13246-014-0277-6
- Print ISSN
- 0158-9938
- Online ISSN
- 1879-5447
- Publisher
- Springer Netherlands
- Additional Links
- Topics
- Keywords
-
- Monte Carlo
- Radionuclide dosimetry
- Dose factors
- Gate
- XCAT
- Industry Sectors
- Authors
-
- Kevin J. Hickson (1)
- Graeme J. O’Keefe (1)
- Author Affiliations
-
- 1. Centre for PET, Austin Health, Studley Rd, Heidelberg, VIC, 3084, Australia
-