Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study
- Andrew M. Scott,
- Dishan H. Gunawardana,
- Joseph Wong,
- Ian Kirkwood,
- Rodney J. Hicks,
- Ivan Ho Shon,
- Jayne E. Ramshaw,
- Peter Robins
- … show all 8 hide
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Purpose
Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans.
Methods
PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented.
Results
PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior.
Conclusion
PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma.
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- Title
- Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study
- Journal
-
European Journal of Nuclear Medicine and Molecular Imaging
Volume 36, Issue 3 , pp 347-353
- Cover Date
- 2009-03-01
- DOI
- 10.1007/s00259-008-0958-z
- Print ISSN
- 1619-7070
- Online ISSN
- 1619-7089
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
-
- PET
- Gallium
- Low-grade lymphoma
- Industry Sectors
- Authors
-
- Andrew M. Scott (1) (2)
- Dishan H. Gunawardana (1)
- Joseph Wong (3)
- Ian Kirkwood (4)
- Rodney J. Hicks (5)
- Ivan Ho Shon (6)
- Jayne E. Ramshaw (7)
- Peter Robins (8)
- Author Affiliations
-
- 1. Centre for PET, Austin Hospital, Studley Rd, Heidelberg, Melbourne, Victoria, 3084, Australia
- 2. Ludwig Institute for Cancer Research, Austin Hospital, Melbourne, Australia
- 3. Southern X-Ray Clinics, The Wesley Hospital, Brisbane, Australia
- 4. Department of Nuclear Medicine and PET, Royal Adelaide Hospital, Adelaide, Australia
- 5. Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia
- 6. Department of Nuclear Medicine & PET, Liverpool Hospital, Sydney, Australia
- 7. Australian and New Zealand Association of Physicians in Nuclear Medicine, Melbourne, Australia
- 8. WA PET/Cyclotron Service, Sir Charles Gairdner Hospital, Perth, Australia