Hyperbaric Oxygen Therapy for Malignancy: A Review
- Jurstine Daruwalla B.Sc,
- Chris Christophi MD
- … show all 2 hide
Rent the article at a discount
Rent now* Final gross prices may vary according to local VAT.
Get AccessAbstract
One unique feature of tumors is the presence of hypoxic regions, which occur predominantly at the tumor center. Hypoxia has a major impact on various aspects of tumor cell function and proliferation. Hypoxic tumor cells are relatively insensitive to conventional therapy owing to cellular adaptations effected by the hypoxic microenvironment. Recent efforts have aimed to alter the hypoxic state and to reverse these adaptations to improve treatment outcome. One way to increase tumor oxygen tensions is by hyperbaric oxygen (HBO) therapy. HBO therapy can influence the tumor microenvironment at several levels. It can alter tumor hypoxia, a potent stimulus that drives angiogenesis. Hyperoxia as a result of HBO also produces reactive oxygen species, which can damage tumors by inducing excessive oxidative stress. This review outlines the importance of oxygen to tumors and the mechanisms by which tumors survive under hypoxic conditions. It also presents data from both experimental and clinical studies for the effect of HBO on malignancy.
- Vaupel, P (1990) Blood flow, oxygen consumption and tissue oxygenation of human tumors. Adv Exp Med Biol 277: pp. 895-905
- Tandara, AA (2004) Oxygen in wound healing—more than a nutrient. World J Surg 28: pp. 294-300
- Grolman, RE (2001) Transcutaneous oxygen measurements predict a beneficial response to hyperbaric oxygen therapy in patients with nonhealing wounds and critical limb ischemia. Am Surg 67: pp. 1072-1080
- Hammarlund, C (1991) Hyperbaric oxygen treatment of healthy volunteers with U.V.-irradiated blister wounds. Burns 17: pp. 296-301
- Thom, SR (1995) Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med 25: pp. 474-480
- Weaver, LK (2002) Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 347: pp. 1057-1067
- Dean, BS (1993) Coma reversal with cerebral dysfunction recovery after repetitive hyperbaric oxygen therapy for severe carbon monoxide poisoning. Am J Emerg Med 11: pp. 616-618
- Hawkins, M (2000) Severe carbon monoxide poisoning: outcome after hyperbaric oxygen therapy. Br J Anaesth 84: pp. 584-586
- Durmaz, E (1999) Carbon monoxide poisoning and hyperbaric oxygen therapy. Br J Nurs 8: pp. 1067-1072
- Wilkinson, D (2004) Hyperbaric oxygen treatment and survival from necrotizing soft tissue infection. Arch Surg 139: pp. 1339-1345
- Henk, JM (1977) Radiotherapy and hyperbaric oxygen in head and neck cancer: final report of first controlled clinical trial. Lancet 2: pp. 101-103
- Petre, PM (2003) Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model. J Thorac Cardiovasc Surg 125: pp. 85-95
- Mayer, R (2005) Hyperbaric oxygen and radiotherapy. Strahlenther Onkol 181: pp. 113-123
- DeCosse, JJ (1966) Influence of high-pressure oxygen and chemotherapy on the AMel 4 hamster melanoma. Cancer Res 26: pp. 287-292
- Takiguchi, N (2001) Use of 5-FU plus hyperbaric oxygen for treating malignant tumors: evaluation of antitumor effect and measurement of 5-FU in individual organs. Cancer Chemother Pharmacol 47: pp. 11-14
- Huang, Z (2003) Hyperoxygenation enhances the tumor cell killing of photofrin-mediated photodynamic therapy. Photochem Photobiol 78: pp. 496-502
- Moulder, JE (1987) Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Rev 5: pp. 313-341
- Knisely, JP (2002) Importance of hypoxia in the biology and treatment of brain tumors. Neuroimaging Clin N Am 12: pp. 525-536
- Puffer, HW (1976) Preliminary observations of oxygen levels in microcirculation of tumors in C3H mice. Adv Exp Med Biol 75: pp. 605-610
- Kizaka-Kondoh, S (2003) Tumor hypoxia: a target for selective cancer therapy. Cancer Sci 94: pp. 1021-1028
- Brizel, DM (1997) Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Physics 38: pp. 285-289
- Dunst, J (2001) Tumor hypoxia and systemic levels of vascular endothelial growth factor (VEGF) in head and neck cancers. Strahlenther Onkol 177: pp. 469-473
- Hockel, M (1999) Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res 59: pp. 4525-4528
- Cvetkovic, D (2001) Increased hypoxia correlates with increased expression of the angiogenesis marker vascular endothelial growth factor in human prostate cancer. Urology 57: pp. 821-825
- Shi Q, et al. Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res 1999;3711–3721
- Cuisnier, O (2003) Chronic hypoxia protects against gamma-irradiation-induced apoptosis by inducing bcl-2 up-regulation and inhibiting mitochondrial translocation and conformational change of bax protein. Int J Oncol 23: pp. 1033-1041
- Vaupel, P (2003) Tumor oxygenation and its relevance to tumor physiology and treatment. Adv Exp Med Biol 510: pp. 45-49
- Vaupel, P (2004) Tumor hypoxia and malignant progression. Methods Enzymol 381: pp. 335-354
- Hockel, M (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: pp. 4509-4515
- Bachtiary, B (2003) Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin Cancer Res 9: pp. 2234-2240
- Hashizume, H (2000) Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol 156: pp. 1363-1380
- Galmarini, CM (2003) Multidrug resistance in cancer therapy: role of the microenvironment. Curr Opin Invest Drugs 4: pp. 1416-1421
- Chaplin, DJ (1987) Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res 47: pp. 597-601
- Sakamoto, M (1993) Phenotype changes in tumor vessels associated with the progression of hepatocellular carcinoma. Jpn J Clin Oncol 23: pp. 98-104
- Toi, M (1994) Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res 85: pp. 1045-1049
- Duque, JL (1999) Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. Urology 54: pp. 523-527
- Karayiannakis, AJ (2003) Serum vascular endothelial growth factor levels in pancreatic cancer patients correlate with advanced and metastatic disease and poor prognosis. Cancer Lett 194: pp. 119-124
- Jacobsen, J (2000) Vascular endothelial growth factor as prognostic factor in renal cell carcinoma. J Urol 163: pp. 343-347
- Akbulut, H (2002) Prognostic role of serum vascular endothelial growth factor, basic fibroblast growth factor and nitric oxide in patients with colorectal carcinoma. Cytokine 20: pp. 184-190
- Ikeda, E (1995) Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 270: pp. 19761-19766
- Ferrara, N (1997) The biology of vascular endothelial growth factor. Endocr Rev 18: pp. 4-25
- Leung, DW (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: pp. 1306-1309
- Horiuchi, A (2002) Hypoxia-induced changes in the expression of VEGF, HIF-1 alpha and cell cycle-related molecules in ovarian cancer cells. Anticancer Res 22: pp. 2697-2702
- Rofstad, EK (1998) Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma. Br J Cancer 77: pp. 897-902
- Ziemer, LS (2001) Hypoxia and VEGF mRNA expression in human tumors. Neoplasia 3: pp. 500-508
- Shweiki, D (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: pp. 843-845
- Plate, KH (1992) Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359: pp. 845-848
- White, FC (1995) VEGF mRNA is reversibly stabilized by hypoxia and persistently stabilized in VEGF-overexpressing human tumor cell lines. Growth Factors 12: pp. 289-301
- Levy, AP (1995) Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270: pp. 13333-13340
- Stein, I (1998) Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol Cell Biol 18: pp. 3112-3119
- Schoch, HJ (2002) Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain 125: pp. 2549-2557
- Iyer, NV (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12: pp. 149-162
- Wang, GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: pp. 5510-5514
- Tang, N (2004) Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6: pp. 485-495
- Forsythe, JA (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: pp. 4604-4613
- Semenza, GL (2001) ‘The metabolism of tumours’: 70 years later. Novartis Found Symp 240: pp. 251-264 CrossRef
- Kuwabara, K (1995) Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl Acad Sci USA 92: pp. 4606-4610
- Hartmann, A (1999) Hypoxia-induced up-regulation of angiogenin in human malignant melanoma. Cancer Res 59: pp. 1578-1583
- Chavey C, et al. IL-8 is a novel marker for breast cancer. Third Int Symp Mol Biol Breast Cancer 2005;7(Suppl 2)
- Benoy, IH (2004) Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clin Cancer Res 10: pp. 7157-7162
- Brown, NS (2000) Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res 60: pp. 6298-6302
- Kunz, M (1999) Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma: a potential mechanism for high tumor aggressiveness. Am J Pathol 155: pp. 753-763
- Giri, D (2001) Interleukin-8 is a paracrine inducer of fibroblast growth factor 2, a stromal and epithelial growth factor in benign prostatic hyperplasia. Am J Pathol 159: pp. 139-147
- D’Agnano, I (1995) DNA ploidy, proliferative index, and epidermal growth factor receptor: expression and prognosis in patients with gastric cancers. Lab Invest 72: pp. 432-438
- Schaeybroeck, S (2005) Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res 11: pp. 7480-7489
- Oh, MJ (2000) Detection of epidermal growth factor receptor in the serum of patients with cervical carcinoma. Clin Cancer Res 6: pp. 4760-4763
- Gazzaniga, P (2001) Detection of epidermal growth factor receptor mRNA in peripheral blood: a new marker of circulating neoplastic cells in bladder cancer patients. clin Cancer Res 7: pp. 577-583
- Graeber, TG (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379: pp. 88-91
- Shaw, P (1992) Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA 89: pp. 4495-4499
- Brown, NS (2001) Hypoxia and oxidative stress in breast cancer; oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res 3: pp. 323-327
- Bergh, J (1995) Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nat Med 1: pp. 1029-1034
- Havrilesky, L (2003) Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol 21: pp. 3814-3825
- Baker, SJ (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244: pp. 217-221
- Chadeneau, C (1995) Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Camcer Res 55: pp. 2533-2536
- Oishi, T (1998) Alteration of telomerase activity associated with development and extension of epithelial ovarian cancer. Obstet Gynecol 91: pp. 568-571
- Kuniyasu, H (1997) Expression of human telomerase RNA is an early event of stomach carcinogenesis. Jpn J Cancer Res 88: pp. 103-107
- Kumaki F, et al. Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas. Hum Pathol 2001;188–195
- Hiyama K, et al. Telomerase activity in small-cell and non-small-cell lung cancers. J Natl Cancer Inst 1995;895–902
- Minamino T, et al. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol 2001;3336–3342
- Ravi, R (2000) Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14: pp. 34-44
- Koukourakis, MI (2001) Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res 61: pp. 1830-1832
- Hockenbery, D (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: pp. 334-336
- Lowe, SW (2000) Apoptosis in cancer. Carcinogenesis 21: pp. 485-495
- Warburg, O (1967) On growth of cancer cells in media in which glucose is replaced by galactose. Hoppe Seylers Z Physiol Chem 348: pp. 1686-1687
- Kondo, Y (2005) Over expression of hypoxia-inducible factor-1alpha in renal and bladder cancer cells increases tumorigenic potency. J Urol 173: pp. 1762-1766
- Semenza, GL (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269: pp. 23757-23763
- Webster, KA (1990) Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts. J Cell Physiol 142: pp. 566-573
- Maxwell, PH (1997) Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94: pp. 8104-8109
- Bustamante, E (1977) High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci USA 74: pp. 3735-3739
- Mathupala, SP (1995) Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. J Biol Chem 270: pp. 16918-16925
- Lu, H (2002) Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis: oncogenes in tumor metabolism, tumorigenesis, and apoptosis. J Biol Chem 277: pp. 23111-23115
- Dang, CV (1997) Oncogenes in tumor metabolism, tumorigenesis, and apoptosis. J Bioenerg Biomembr 29: pp. 345-354
- Elstrom, RL (2004) Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64: pp. 3892-3899
- Cohen, G (1963) Glutathione peroxidase: the primary agent for the elimination of hydrogen peroxide in erythrocytes. Biochemistry 2: pp. 1420-1428
- Talior, I (2003) Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice. Am J Physiol Endocrinol Metab 285: pp. E295-E302
- McMullin, MF (1999) The molecular basis of disorders of red cell enzymes. J Clin Pathol 52: pp. 241-244 CrossRef
- Aw, TY (2003) Cellular redox: a modulator of intestinal epithelial cell proliferation. News Physiol Sci 18: pp. 201-204
- Kamata, H (1999) Redox regulation of cellular signalling. Cell Signal 11: pp. 1-14
- Benhar, M (2002) ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep 3: pp. 420-425
- Blokhina, O (2003) Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann bot 91: pp. 179-194
- Sharkey, S (2000) Current indications for hyperbaric oxygen therapy. Austr Defence Force Health 1: pp. 64-72
- Jackson, AL (2001) The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat Res 477: pp. 7-21
- Szatrowski, TP (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51: pp. 794-798
- Wiseman, H (1996) Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 313: pp. 17-29
- Kuhn, MA (2003) Oxygen free radicals and antioxidants. AJN Am J Nurs 103: pp. 58-62
- Laurent, A (2005) Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 65: pp. 948-956
- Behrend, L (2003) Reactive oxygen species in oncogenic transformation. Biochem Soc Trans 31: pp. 1441-1444
- Arnold, RS (2001) Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci USA 98: pp. 5550-5555
- Suh, YA (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature 401: pp. 79-82
- Shen, H (1997) Importance of glutathione and associated enzymes in drug response. Oncol Res 9: pp. 295-302
- Harrison, LB (2002) Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 7: pp. 492-508
- Kaelin, CM (1990) The effects of hyperbaric oxygen on free flaps in rats. Arch Surg 125: pp. 607-609
- Kong, Q (2000) A threshold concept for cancer therapy. Med Hypotheses 55: pp. 29-35
- Hileman, EO (2004) Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity. Cancer Chemother Pharmacol 53: pp. 209-219
- Portakal, O (2000) Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 33: pp. 279-284
- Choi, AM (1996) Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 15: pp. 9-19
- Toyokuni, S (1995) Persistent oxidative stress in cancer. FEBS Lett 358: pp. 1-3
- Zhou, S (2001) Doxorubicin-induced persistent oxidative stress to cardiac myocytes. Toxicol Lett 121: pp. 151-157
- Gackowski, D (2002) Persistent oxidative stress in colorectal carcinoma patients. Int J Cancer 101: pp. 395-397
- Goda, N (2003) Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 23: pp. 359-369
- Baish, JW (1996) Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model. Microvasc Res 51: pp. 327-346
- Alagoz, T (1995) Evaluation of hyperbaric oxygen as a chemosensitizer in the treatment of epithelial ovarian cancer in xenografts in mice. Cancer 75: pp. 2313-2322
- Thom SR. Hyperbaric Oxygen Therapy: A Committee Report. Bethesda, Undersea and Hyperbaric Medical Society, 1992;20814
- Zamboni, WA (1989) The effect of acute hyperbaric oxygen therapy on axial pattern skin flap survival when administered during and after total ischemia. J Reconstr Microsurg 5: pp. 343-350
- Erdmann, D (1995) Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice. Undersea Hyperb Med 22: pp. 395-399
- Granowitz, EV (2002) Exposure to increased pressure or hyperbaric oxygen suppresses interferon-gamma secretion in whole blood cultures of healthy humans. Undersea Hyperb Med 29: pp. 216-225
- Marx, RE (1990) Relationship of oxygen dose to angiogenesis induction in irradiated tissue. Am J Surg 160: pp. 519-524
- Meltzer, T (1986) The effect of hyperbaric oxygen on the bursting strength and rate of vascularization of skin wounds in the rat. Am Surg 52: pp. 659-662
- Feldmeier, J (2003) Hyperbaric oxygen: does it promote growth or recurrence of malignancy?. Undersea Hyperb Med 30: pp. 1-18
- Hunt, TK (1988) The physiology of wound healing. Ann Emerg Med 17: pp. 1265-1273
- Marx, RE (1987) Studies in the radiobiology of osteoradionecrosis and their clinical significance. Oral Surg Oral Med Oral Pathol 64: pp. 379-390
- Marx, RE, Johnson, RP Problem wounds in oral and maxillofacial surgery: the role of hyperbaric oxygen. In: Davis, IC, Hunt, TK eds. (1988) Problem Wounds: the Role of Oxygen. Elsevier, New York, pp. 65-123
- Phillips, SJ. (2000) Physiology of wound healing and surgical wound care. ASAIO J 46: pp. S2-S5
- Conconi, MT (2003) Effects of hyperbaric oxygen on proliferative and apoptotic activities and reactive oxygen species generation in mouse fibroblast 3T3/J2 cell line. J Invest Med 51: pp. 227-232
- Lian, QL (1995) Effects of hyperbaric oxygen on S-180 sarcoma in mice. Undersea Hyperb Med 22: pp. 153-160
- Johnson RJR, Lauchlan SC. Epidermoid carcinoma of the cervix treated by 60Co therapy and hyperbaric oxygen. In: Proceedings of the third International Congress on Hyperbaric Medicine, 1966;648–652
- Shewell, J (1980) The effect of hyperbaric oxygen treatment on pulmonary metastasis in the C3H mouse. Eur J Cancer (Oxf) 16: pp. 253-259
- McMillan, T (1989) The effect of hyperbaric oxygen on oral mucosal carcinoma. Laryngoscope 99: pp. 241-244
- Valaitis, J (1968) Effect of hyperbaric oxygen and nitrogen mustard (NSC-762) on Ehrlich ascites tumor. Cancer Chemother Rep 52: pp. 405-412
- Cade, IS (1967) Megavoltage radiotherapy in hyperbaric oxygen: a controlled trial. Cancer 20: pp. 817-821
- Eltorai I, et al. Does hyperbaric oxygenation provoke an occult carcinoma in man? In: Proceedings of the VIII International Conference on Hyperbaric Medicine, North Carolina, 1987;18–27
- Bean, JW (1966) Reaction of Ehrlich ascites cells in exposure to oxygen at high pressure. Cancer Res 26: pp. 2380-2385
- McCredie, JA (1966) Effects of hyperbaric oxygen on growth and metastases of the C3HBA tumor in the mouse. Cancer 19: pp. 1537-1542
- Suit, HD (1966) Effect of daily exposure to high pressure oxygen on tumor growth. Am J Roentgenol Radium Ther Nucl Med 97: pp. 1019-1022
- Johnson, RE (1967) Hyperbaric oxygen effect on experimental tumor growth. Radiology 88: pp. 775-777
- Feder, BH (1968) The effect of hyperbaric oxygen on pulmonary metastases in C3H mice. Radiology 90: pp. 1181-1184
- Johnson, RJR (1971) The effect of hyperbaric oxygen on tumor metastases in mice. Clin Radiol 22: pp. 538-540
- Mestrovic, J (1990) Suppression of rat tumor colonies in the lung by oxygen at high pressure is a local effect. Clin Exp Metastasis 8: pp. 113-119
- Dettmer, CM (1968) The effect of increased oxygen tensions upon animal tumor growth. Am J Roentgenolo Radium Ther Nucl Med 102: pp. 804-810
- Bradfield, JJ (1996) Rapid progression of head and neck squamous carcinoma after hyperbaric oxygenation. Otolaryngol Head Neck Surg 114: pp. 793-797
- Brenk, HA (1967) An analysis of the progression and development of metastases in patients receiving x-radiation in hyperbaric oxygen. Clin Radiol 18: pp. 54-61
- Dische, S (1978) Hyperbaric oxygen: the Medical Research Council trials and their clinical significance. Br J Radiol 51: pp. 888-894
- Perrins, DJD, Wiernik, G Controlled trials in carcinoma of the bladder. In: Smith, G eds. (1977) Proceedings of the Sixth International Congress on Hyperbaric Medicine. University Press, Aberdeen, Scotland, pp. 253-258
- Henk, JM (1986) Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: a rationale for hypoxic cell sensitizers?. Int J Radiat Oncol Biol Phys 12: pp. 1339-1341
- Sealy, R (1986) Irradiation with misonidazole and hyperbaric oxygen: final report on a randomized trial in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 12: pp. 1343-1346
- Granstrom, G (1996) Hyperbaric oxygen therapy decreases the rejection rate of osseointegrated implants after radiotherapy. Strahlenther Onkol 172: pp. 20-21
- Maier, A (2000) Combined photodynamic therapy and hyperbaric oxygenation in carcinoma of the esophagus and the esophago-gastric junction. Eur J Cardiothorac Surg 18: pp. 649-655
- Gray, LH (1953) The concentration of oxygen dissolved in tissue at the time or irradiation as factor in radiotherapy. Br J Radiol 26: pp. 638 CrossRef
- Chen, Q (2002) Improvement of tumor response by manipulation of tumor oxygenation during photodynamic therapy. Photochem Photobiol 76: pp. 197-203
- Teicher, BA (1981) Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res 41: pp. 73-81
- Evans, JC (1969) Metastasis following radiotherapy in hyperbaric oxygen. Radiology 93: pp. 1155-1157
- Martin DF, et al. Enhancement of tumor radiation response by the combination of a perfluorochemical emulsion and hyperbaric oxygen. Int J Radiat Oncol Biol Phys 1987;747–751
- Frid, IA (1989) Effects of hyperbaric oxygenation on tumor growth. Vopr Onkol 35: pp. 970-973
- Granstrom G, Westin T, Lyden E, Bengt C, Magnusson BG, Edstrom S. Hyperbaric oxygenation does not stimulate experimental tumour growth. In: Proceedings from the XVIth EUBS meeting, Amsterdam, 1990;121–129
- Headley, DB (1991) The effect of hyperbaric oxygen on growth of human squamous cell carcinoma xenografts. Arch Otolaryngol Head Neck Surg 117: pp. 1269-1272
- Sklizovic, D (1993) Hyperbaric oxygen therapy and squamous cell carcinoma cell line growth. Head Neck 15: pp. 236-240
- McDonald, KR (1996) Effect of hyperbaric oxygenation on existing oral mucosal carcinoma. Laryngoscope 106: pp. 957-959
- Shi, Y (2005) Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature. Head Neck 27: pp. 362-369
- Johnson, RJ (1974) Sequential study on the effect of the addition of hyperbaric oxygen on the 5 year survival rates of carcinoma of the cervix treated with conventional fractional irradiations. Am J Roentgenol Radium Ther Nucl Med 120: pp. 111-117
- Bennett, MB, Sealy, R, Hockly, J The treatment of stage III squamous cell carcinoma of the cervix in air and in hyperbaric oxygen. In: Smith, G eds. (1977) Proceedings of the Sixth International Congress on Hyperbaric Oxygen. University press, Aberdeen, Scotland, pp. 247-252
- Henk, JM (1977) Radiotherapy and hyperbaric oxygen in head and neck cancer: interim report of second clinical trial. Lancet 2: pp. 104-105
- Watson, ER (1978) Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix. Br J Radiol 51: pp. 879-887
- Brady, LW (1981) Hyperbaric oxygen therapy for carcinoma of the cervix—stages IIB, IIIA, IIIB and IVA: results of a randomized study by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 7: pp. 991-998
- Granstrom G. Tumor recurrence and development of new head and neck cancers after HDO2—treatment a prospective clinical study. In: Proceedings: International Joint Meeting on Hyperbaric and Underwater Medicine, Milan, 1996;47–60
- Dische, S (1999) Carcinoma of the cervix and the use of hyperbaric oxygen with radiotherapy: a report of a randomised controlled trial. Radiother Oncol 53: pp. 93-98
- Haffty, BG (1999) Radiation therapy with hyperbaric oxygen at 4 atmospheres pressure in the management of squamous cell carcinoma of the head and neck: results of a randomized clinical trial: carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: long-term tumor control and complications. Cancer J Sci Am 5: pp. 341-347
- Haffty, BG (1999) Carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: long-term tumor control and complications. Int J Radiat Oncol Biol Phys 45: pp. 13-20
- Kohshi, K (1999) Effects of radiotherapy after hyperbaric oxygenation on malignant gliomas. Br J Cancer 80: pp. 236-241
- Feldmeier, JJ (1996) Hyperbaric oxygen an adjunctive treatment for delayed radiation injuries of the abdomen and pelvis. Undersea Hyperb Med 23: pp. 205-213
- Horsman, M (1997) The Oxygen Effect: Basic Clinical Radiobiology. Arnold, London
- Overgaard, J (1996) Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol 6: pp. 10-21
- Lartigau E, at al. Hyperbaric oxygen in the treatment of radio-induced lesions in normal tissues. Presented to the European Society for Therapuetic Radiology and Oncology and European Committee for Hyperbaric Medicine, Lisbon, 2001
- Kalns, J (1998) The effect of hyperbaric oxygen on growth and chemosensitivity of metastatic prostate cancer. Anticancer Res 18: pp. 363-367
- Stuhr, LE (2004) Hyperbaric oxygen alone or combined with 5-FU attenuates growth of DMBA-induced rat mammary tumors. Cancer Lett 210: pp. 35-40
- Narkowicz, CK (1993) Hyperbaric oxygen therapy increases free radical levels in the blood of humans. Free Radic Res Commun 19: pp. 71-80
- Dennog, C (1999) Analysis of oxidative DNA damage and HPRT mutations in humans after hyperbaric oxygen treatment. Mutat Res 431: pp. 351-359
- Kalns, JE (1999) Exposure to hyperbaric oxygen induces cell cycle perturbation in prostate cancer cells. In Vitro Cell Dev Biol Anim 35: pp. 98-101
- Teas, J (2004) Can hyperbaric oxygen therapy reduce breast cancer treatment-related lymphedema? A pilot study. J Womens Health (Larchmt) 13: pp. 1008-1018 CrossRef
- Yarnold J. Phase II randomized study of hyperbaric oxygen therapy versus standard management in women with chronic arm lymphedema after radiotherapy for early breast cancer. Clinical trial in progress, UK, 2004
- Maier, A (2000) Does hyperbaric oxygen enhance the effect of photodynamic therapy in patients with advanced esophageal carcinoma? A clinical pilot study. Endoscopy 32: pp. 42-48
- Tomaselli, et al. Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer—a clinical pilot study. Lasers Surg Med 2001;28:399–403
- Title
- Hyperbaric Oxygen Therapy for Malignancy: A Review
- Journal
-
World Journal of Surgery
Volume 30, Issue 12 , pp 2112-2131
- Cover Date
- 2006-12-01
- DOI
- 10.1007/s00268-006-0190-6
- Print ISSN
- 0364-2313
- Online ISSN
- 1432-2323
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Industry Sectors
- Authors
- Author Affiliations
-
- 1. Department of Surgery, University of Melbourne, Austin Hospital, Level 8 Lance Townsend Building, Austin Health, Studley Road, Heidelberg, Victoria, 3084, Australia